![]() ![]() Enrofloxacin is also active against Staphylococci and thus is commonly used for skin infections. This medication may be used in either dogs or cats to combat different types of infections, especially those involving Pseudomonas. Mammalian DNA gyrase is of a completely different shape and remains unharmed. The fluoroquinolone antibiotic deactivates DNA gyrase making the reading of DNA impossible. Segments to be used must be uncoiled by an enzyme called DNA gyrase. DNA is tightly coiled in order to fit inside a cell. They are available as tablets and are not associated with the serious side effects that plagued the aminoglycoside group.įluoroquinolones act by deactivating bacterial enzymes necessary for the transcription of DNA. These medications are active against many bacterial types including Pseudomonas. With these kinds of side effects and the ability to treat Pseudomonas limited to hospitalized patients (where injections could be given regularly), the battle with Pseudomonas was far from won.Ī major breakthrough was the development of the fluoroquinolone class of antibiotics (including enrofloxacin, its counterpart for human use ciprofloxacin, and several others). Eventually, antibiotics (the aminoglycoside class) were developed that could kill Pseudomonas but they were available only as injectable products and they had the potential to cause significant kidney damage if used too long. As different antibiotics were developed, different types of bacteria were conquered, yet one bacterial species remained seemingly invincible: Pseudomonas aeruginosa. Until sulfa drugs came on the scene in the 1940s, our efforts to combat bacterial infection were largely ineffective. ![]() Note the concerns about retinal damage and watch your cat for dilated pupils, bumping into things, misjudging jumping distances or other signs of vision loss. ![]()
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